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《医学前沿(英文)》 2022年 第16卷 第2期 页码 240-250 doi: 10.1007/s11684-021-0909-7
《医学前沿(英文)》 2022年 第16卷 第2期 页码 176-184 doi: 10.1007/s11684-021-0885-y
关键词: small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 297-310 doi: 10.1007/s11684-016-0452-0
Studies on coding genes, miRNAs, and lncRNAs during erythroid development have been performed in recent years. However, analysis focusing on the integration of the three RNA types has yet to be done. In the present study, we compared the dynamics of coding genes, miRNA, and lncRNA expression profiles. To explore dynamic changes in erythropoiesis and potential mechanisms that control these changes in the transcriptome level, we took advantage of high throughput sequencing technologies to obtain transcriptome data from cord blood hematopoietic stem cells and the following four erythroid differentiation stages, as well as from mature red blood cells. Results indicated that lncRNAs were promising cell marker candidates for erythroid differentiation. Clustering analysis classified the differentially expressed genes into four subtypes that corresponded to dynamic changes during stemness maintenance, mid-differentiation, and maturation. Integrated analysis revealed that noncoding RNAs potentially participated in controlling blood cell maturation, and especially associated with heme metabolism and responses to oxygen species and DNA damage. These regulatory interactions were displayed in a comprehensive network, thereby inferring correlations between RNAs and their associated functions. These data provided a substantial resource for the study of normal erythropoiesis, which will permit further investigation and understanding of erythroid development and acquired erythroid disorders.
关键词: erythroid differentiation hematopoietic stem cell RNA-seq miRNA lncRNA
The critical importance of epigenetics in autoimmune-related skin diseases
《医学前沿(英文)》 2023年 第17卷 第1期 页码 43-57 doi: 10.1007/s11684-022-0980-8
关键词: epigenetics autoimmune-related skin diseases DNA methylation histone modifications noncoding RNAs
A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 108-111 doi: 10.1007/s11684-014-0344-0
Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.
关键词: gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib
李石营, 钱天梅, 王星辉, 刘杰, 顾晓松
《工程(英文)》 2017年 第3卷 第1期 页码 3-15 doi: 10.1016/J.ENG.2017.01.005
组织工程是医学科学中一个相对较新但发展迅速的领域。非编码RNA(ncRNA) 是不编码蛋白质的功能性RNA 分子,它们可以调节细胞的行为、改变组织的生物学环境。虽然以对ncRNA 作为治疗靶点尚未进入临床实践,但ncRNA 在组织工程中的应用已经吸引了越来越多的关注,而且对ncRNA 的调节作用和释放方法的深入探讨可以促进其在组织工程中的应用。本文简要介绍了ncRNA 在神经、皮肤、肝脏、血管和肌肉的调控作用和可能的释放方法及其潜在的治疗应用价值。
关键词: 组织工程 非编码RNA(ncRNA) microRNA(miRNA) 神经 皮肤 肝脏 血管系统 肌肉
Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine
Mao CHEN,Yonglin JU
《能源前沿(英文)》 2016年 第10卷 第1期 页码 37-45 doi: 10.1007/s11708-015-0390-6
关键词: thermo-acoustic Stirling engine small-scale simulation experiment
Discovery of small molecule degraders for modulating cell cycle
《医学前沿(英文)》 页码 823-854 doi: 10.1007/s11684-023-1027-5
Fine-tuning cell organelle dynamics during mitosis by small GTPases
《医学前沿(英文)》 2022年 第16卷 第3期 页码 339-357 doi: 10.1007/s11684-022-0926-1
Gut microbiota and its implications in small bowel transplantation
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 239-248 doi: 10.1007/s11684-018-0617-0
The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.
关键词: gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 157-171 doi: 10.1007/s11684-013-0272-4
Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.
关键词: non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling
Performance prediction of switched reluctance generator with time average and small signal models
Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM
《能源前沿(英文)》 2013年 第7卷 第1期 页码 56-68 doi: 10.1007/s11708-012-0216-8
关键词: generator reluctance switching model small signal model time average model
《医学前沿(英文)》 2023年 第17卷 第1期 页码 18-42 doi: 10.1007/s11684-022-0976-4
关键词: non-small cell lung cancer driver mutations treatment strategy resistant mechanism immune-checkpoint inhibitors
《医学前沿(英文)》 2022年 第16卷 第4期 页码 610-617 doi: 10.1007/s11684-021-0827-8
关键词: bevacizumab elderly patient advanced non-small-cell lung cancer overall survival toxicity
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 15-26 doi: 10.1007/s11705-017-1629-z
关键词: biosensor small molecule product transcription factor riboswitch high-throughput screening
标题 作者 时间 类型 操作
Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing
期刊论文
Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational
期刊论文
Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during
null
期刊论文
Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine
Mao CHEN,Yonglin JU
期刊论文
Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis
null
期刊论文
Performance prediction of switched reluctance generator with time average and small signal models
Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM
期刊论文
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future
期刊论文
Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell
期刊论文